Calcium Gluconate: (Moderate) Calcitonin is given to hypercalcemic patients to reduce serum calcium concentrations. http://www.upandaway.org. Tell all of your health care providers that you take Miacalcin ( calcitonin injection). If the solution is discolored or contains particles, do not use it, and call your pharmacist. Dispose of all empty syringes and vials as directed by your healthcare provider. The information for 34 of these medications (38%) was obtained from the official prescribing information. For smaller ulcers, interrupt therapy until healing occurs. The recommended starting dose is 100 IU every 6 to 8 hours by subcutaneous or intramuscular injection. The presence of antibodies appears to bear no relationship to allergic reactions, which are rare. If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088). In patients at risk for hypocalcemia, provisions for parenteral calcium administration should be available during the first several administrations of calcitonin salmon and serum calcium and symptoms of hypocalcemia should be monitored. 1 Development of neutralising antibodies to calcitonin. MIACALCIN (calcitonin salmon) injection, solution. tell your doctor and pharmacist if you are allergic to calcitonin salmon or any other medications. It may also be used to prevent bone loss in women with postmenopausal osteoporosis and to treat hypercalcemia (too much calcium in the blood). 1. Room Temperature Abciximab 2-mg/mL injection Allergen extract concentrate Alprostadil injection Alteplase Atracurium injection Becaplermin 0.01% Botulinum toxin type-A 100 units Calcitonin injection Calcitonin nasal spray Calcitonin salmon intranasal Candida albicans Monitor serum calcium concentrations closely in patients with severe renal impairment (CrCl less than 30 mL/minute) or renal failure (and/or on dialysis) receiving calcimimetics. Calcitonin-salmon Nasal Spray:Before the first dose, the nasal spray should be at room temperature. endobj Calcifediol: (Moderate) Calcitonin is given to hypercalcemic patients to reduce serum calcium concentrations. This suggests an increased risk of malignancies in calcitonin salmon-treated patients compared to placebo-treated patients. Miacalcin injection is available as a clear, colorless, sterile solution of synthetic calcitonin salmon, USP in individual 2 mL multi-dose vials containing 200 USP Units per mL. @ }PM#!.;wfpEk#=&rsn|f#{wqU~o:{c]n_oO?g=w O_w-n2XS1m7~_\_/v1EcNd~sy~K7Gc8U9b8Y93\Xx[vWkkU ] c { pY 6 *| p t)8 v{ pRp0 87 7e Use calcitonin salmon injection exactly as directed. Calcium Carbonate; Simethicone: (Moderate) Calcitonin is given to hypercalcemic patients to reduce serum calcium concentrations. endstream endobj 128 0 obj <>stream It is not known if the substance is excreted in human milk. Concomitant use of calcitonin and lithium may lead to a reduction in plasma lithium concentrations. endobj An increase in serum calcium concentrations helps to reduce bone resorption and loss of bone mass, and offsets the effect of calcitonin in lowering serum calcium levels. The effect is more evident on initiation of therapy and tends to decrease or disappear with continued administration or a reduction in dose. Lithium: (Moderate) Reduced serum lithium concentrations have been observed in previously stabilized patients who initiated daily calcitonin salmon subcutaneous injections for osteoporosis. [0 /XYZ 69.5999999 Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. /Annots 20 0 R Miacalcin injection is indicated for the early treatment of hypercalcemic emergencies, along with other appropriate agents, when a rapid decrease in serum calcium is required, until more specific treatment of the underlying disease can be accomplished. Fortical bottle in use: 2025C, in upright position for up to 30 days. 3 In case of patients with high bone remodelling (Paget's disease and young patients) a transient decrease of calcemia may occur between the 4th and the 6th hour after administration, usually asymptomatic. Osteoporosis is a disease that causes bones to weaken and break more easily. [0 /XYZ 69.5999999 /ca 1.0 Human milk naturally contains some calcitonin and its precursor, procalcitonin. Very bad and sometimes deadly allergic side effects have rarely happened. Reporting suspected adverse reactions after authorisation of the medicinal product is important. Maintenance: 50 units (0.25 mL) daily or every other day; higher dosage (100 units daily) appropriate in patients with serious deformity or neurologic involvement. The U.S. Pharmacopeia's definition of room temperature (20-25 degrees C [68-77 degrees F]) was used for this review. Fortical: To prime pump, hold bottle upright and depress the 2 white side arms of pump toward the bottle at least 5 times until full spray is produced. There are no data regarding a potential influence of calcitonin on human fertility. << Please enter a Recipient Address and/or check the Send me a copy checkbox. Calcitonin receptor down-regulation may also result in a reduced clinical response in a small percentage of patients following long-term therapy. Possibility of hypocalcemic tetany following parenteral administration; have calcium injection readily available, particularly during first several doses of parenteral calcitonin. Sub-Q injection preferred for patient self-administration. Administer by sub-Q or IM injection (Paget disease of bone, hypercalcemia, postmenopausal osteoporosis) or intranasally (postmenopausal osteoporosis). Discard the bottle after 30 doses. Brand names: Fortical, Miacalcin endobj [0 /XYZ 43.6799999 Although smaller ulcers often heal without withdrawal of calcitonin nasal spray, the medication should be discontinued temporarily until healing occurs. Fortical bottle in use: 20-25C, in upright position for up to 30 days. This medicine is available only with your doctor's prescription. If severe ulceration of the nasal mucosa occurs, calcitonin nasal spray should be discontinued. It may also be added to existing therapeutic regimens for hypercalcemia such as intravenous fluids and furosemide, oral phosphate or corticosteroids, or other agents. [27980] [57624] The PROOF study indicates a potential reduction in new vertebral fractures with use. Victor Cohen,1,2 Samantha P. Jellinek,1 Leftherios Teperikidis,1 Elliot Berkovits,1 William M. Goldman 1,2 1Maimonides Medical Center, Brooklyn, NY 2Long Island University, Brooklyn, NY. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. Specific guidelines for dosage adjustments in renal impairment are not available; it appears that no dosage adjustments are needed. Calcitonin is a human hormone that is also found in salmon. Because calcitonin is a peptide, the possibility of systemic allergic reactions exists and allergic-type reactions including isolated cases of anaphylactic shock have been reported in patients receiving calcitonin. Adverse drug reactions from multiple sources including clinical trials and post-marketing experience are listed by MedDRA system organ class. For the treatment of osteoporosis adequate intake of calcium salts are necessary in conjunction with calcitonin. Destroyed in GI tract; administer parenterally or intranasally. For the treatment of osteoporosis adequate intake of vitamin D is necessary in conjunction with calcitonin. American Society of Health-System Pharmacists, Inc., 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814. >> k_b Salmon calcitonin is rapidly absorbed. %PDF-1.4 % In animals, salmon calcitonin has been shown to decrease lactation and to be excreted in milk (see section 5.3). Miacalcin Nasal Spray Storage (or generic equivalent): After opening, store bottle in use at room temperature between 20 and 25 degrees C (68 and 77 degrees F) in an upright position, for up to 35 days. For the treatment of hypercalcemia, calcium supplements should be avoided. >> To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location one that is up and away and out of their sight and reach. 100 International Units IM or subcutaneously once daily. The frequencies of the above listed undesirable effects are partly based on results from clinical trials with calcitonin nasal spray. Dissolve in 0.1 M Suitability requirements hydrochloric acid. Miacalcinbottle in use: 1530C, in upright position for up to 35 days. Calcitonin salmon has same pharmacologic activity as calcitonin human, but calcitonin salmon is more potent and has longer duration of action. Calcium Carbonate; Famotidine; Magnesium Hydroxide: (Moderate) Calcitonin is given to hypercalcemic patients to reduce serum calcium concentrations. 2022 Viatris Inc. All Rights Reserved. The U.S. Pharmacopeia's definition of room temperature (20-25 C [68-77 F]) was used for this review. The calcium-lowering effect of calcitonin is caused both by a decrease in the efflux of calcium from the bone to the ECF and inhibition of renal tubular reabsorption of calcium. Discard the bottle after 30 doses. Calcium salts, including calcium carbonate, can elevate serum calcium concentrations and antagonize the effects of the calcitonin for this condition. Let the solution warm to room temperature before administration. To prime the pump before it is used for the first time, the bottle should be held upright and the two white With parenteral therapy, nausea, vomiting, injection site reaction, flushing of the face, ears, hands, and feet. Store in a refrigerator (2C-8C). Hypersensitivity Reactions: Serious hypersensitivity reactions have been reported in patients receiving Miacalcin injection, e.g., bronchospasm, swelling of the tongue or throat, anaphylactic shock, and death due to anaphylaxis. For the treatment of osteoporosis adequate intake of calcium salts are necessary in conjunction with calcitonin. A controlled study, which was prematurely discontinued, failed to demonstrate any benefit of calcitonin-salmon on fracture rate. Calcitonin 100 IU/1 ml solution for injection and infusion . The recommended dosage is 100 IU daily or 50 IU twice daily administered subcutaneously or intramuscularly. %%EOF endobj /CA 1.0 The bioavailability of intranasal calcitonin-salmon appears to be variable. ` [q`o` nJ| p >=0aE/ic*{5;_/X. >> The development of these antibodies is not usually related to loss of clinical efficacy, although their presence in a small percentage of patients following long-term therapy with calcitonin may result in a reduced response to the product. You must declare any conflicts of interest related to your comments and responses. 310.559999 0] 150 0 obj <>stream Increased urinary lithium clearance is a proposed mechanism for the interaction. Administer dose by placing nozzle in nostril with head in upright position and firmly depressing pump toward bottle. Within each system organ class, the adverse drug reactions are ranked by frequency, with the most frequent reactions first. Purpose. In a large multi-centered, double-blind, randomized clinical study of 942 patients using calcitonin-salmon nasal spray, geriatric patients age 65 to 74 years old accounted for 49.5% of patients and those aged 75 years or more accounted for 21%. From a microbiological point of view, this medicine should be used immediately after it has reached room temperature if it is to be injected or immediately after dilution in 0.9% w/v sodium chloride in soft PVC bags only, if it is to be infused. Calcitonin 400 IU/2 ml solution for i njection and infusion . Data are inadequate to support use of calcitonin in children. Calcitonin acts primarily on bone, but direct renal effects and actions on the gastrointestinal tract are also recognized. AHFS Patient Medication Information. There is insufficient evidence to support the use of salmon calcitonin in conditions associated with paediatric osteoporosis. Calcium Carbonate: (Moderate) Calcitonin is given to hypercalcemic patients to reduce serum calcium concentrations. Other reported clinical experience with calcitonin-salmon injection or nasal sprays has not identified differences in responses between the elderly and younger patients, but greater sensitivity of some older individuals cannot be ruled out. $@D` J Vn)$ @bP1# H #O /SA true It is not intended to be and should not be interpreted as medical advice or a diagnosis of any health or fitness problem, condition or disease; or a recommendation for a specific test, doctor, care provider, procedure, treatment plan, product, or course of action. It is not known whether salmon calcitonin crosses the placental barrier. Off-label: Use is not currently included in the labeling approved by the US Food and Drug Administration. was insufficient regarding room- temperature stability and pharma- . Calcitonin may be considered for women who can not or will not take more effective agents; do not prescribe in early menopause as benefit/efficacy has not been observed within the first 5 years of menopause onset. [27980] [52559] [57624]Calcitonin is a hypocalcemic hormone whose effects are generally opposite those of parathyroid hormone (PTH). Before priming the pump and using a new bottle, allow it to reach room temperature. The duration of effect is 0.512 hours after IV administration. Nausea, vomiting, flushing and dizziness are known to be dose dependent when calcitonin is administered parenterally. Generic alternatives may be available. For the treatment of hypercalcemia, calcium supplements should be avoided. Activity of calcitonin salmon expressed in terms of International Units (units). Miacalcin Injection should be reserved for patients who refuse or cannot tolerate estrogens or in whom estrogens are contraindicated. Calcitonin is excreted primarily in the urine as inactive metabolites. For the treatment of hypercalcemia, calcium supplements should be avoided. Vitamin D analogs can elevate serum calcium concentrations and antagonize the effects of the calcitonin for this condition. By using this Site you agree to the following, By using this Site you agree to the following, Miacalcin injection prescribing information. If there is anything . /Producer ( w k h t m l t o p d f) Calcitonin-salmon appears to have actions essentially identical to endogenous calcitonin of mammalian origin, but its potency per mg is greater than endogenous calcitonin, and it has a longer duration of action. For additional instructions see sections 6.3 and 6.6. Experience with calcitonin in children with idiopathic juvenile osteoporosis is very limited; the relationship between this disorder and postmenopausal osteoporosis is not established. Remaining contents should be discarded. M I A C A L C I N \( c a l c i t o n i n s a l m o n \) i n j e c t i o n , s y n t h e t i c , f o r s u b c u t a n e o u s o r i n t r a m u s c u l a r u s e I n i t i a l U . $E}kyhyRm333: }=#ve For the treatment of hypercalcemia, calcium supplements should be avoided. The usual provisions should be made for emergency treatment if such a reaction occurs. Calcitonin salmon injection is used to treat osteoporosis in postmenopausal women. If your usual dose is every other day, use the missed dose as soon as you remember it, either on the regularly scheduled day or the next day. hb```M~ cc`aq@a/O(C" H82t*\S, j2UFMzCD(ztZh PZa0J i`1@ 0 Calcitonin salmon prepared by recombinant DNA technology is structurally identical to calcitonin salmon produced by chemical synthesis. For the treatment of osteoporosis adequate intake of vitamin D is necessary in conjunction with calcitonin. Data regarding the recommended maximum duration that refrigerated medications available in hospital pharmacies may be stored safely at room t 3R `j[~ : w! This branded product is no longer on the market. Prevention of acute bone loss due to sudden immobilisation such as in patients with recent osteoporotic fractures. ADVERSE REACTIONS: The most common adverse reactions are nausea with or without vomiting (10%), injection site inflammation (10%), and flushing of the face or hands (2% to 5%). Common Miacalcin side effects may include: bleeding from your nose; runny or stuffy nose; dryness, itching, tenderness, or general discomfort of your nose; or. Analyses of randomised controlled trials conducted in patients with osteoarthritis and osteoporosis have shown that calcitonin is associated with a statistically significant increase in the risk of cancer compared to patients treated with placebo. May 20, 2021, 19:48 ET. The result is a decrease in urinary calcium. Peak effects are observed within 4 hours after parenteral administration. Calcitonin should be used during pregnancy only if treatment is considered absolutely essential by the physician. An increase in serum calcium concentrations helps to reduce bone resorption and loss of bone mass, and offsets the effect of calcitonin in lowering serum calcium levels. Solutions for infusion should be prepared immediately before use in soft plastic PVC infusion bags. Nausea/vomiting are less frequent when the injection is done in the evening and after meals. Development of neutralising antibodies to calcitonin.1. /Parent 2 0 R For the treatment of hypercalcemia, calcium supplements should be avoided. Before preparing a dose, look at the vial. The duration of effect is 824 hours after intramuscular administration. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme at www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store. CARLSBAD, Calif., May 20, 2021 /PRNewswire/ -- Leucadia Pharmaceuticals, a U.S. leader in generic injectables and the commercial arm of Custopharm, Inc., today announced . The dose of lithium may require adjustment. 5 0 obj CONTRAINDICATIONS: Hypersensitivity to calcitonin salmon or any of the excipients. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. The metabolic fate of calcitonin has not been clearly established, but it is believed to be rapidly degraded by the kidneys, blood, and peripheral tissues into smaller inactive fragments. Therefore, a nasal examination should be performed prior to the start of treatment with nasal calcitonin and at anytime nasal complaints occur. Calcium salts, including calcium carbonate, can elevate serum calcium concentrations and antagonize the effects of the calcitonin for this condition. ;JrhxKXl]qXUp&t\eEj(Qf`9tG&*3?b6Ed!.DSO1^y6lh{\65 {5;x=FSNu'J+T;!B a0LC/%(1 Specific guidelines for dosage adjustments in hepatic impairment are not available; it appears that no dosage adjustments are needed. Duplication for commercial use must be authorized by ASHP. All material on this website is protected by copyright, Copyright 1994-2023 by WebMD LLC. 10 0 obj Calcitonin has a short absorption half-life of 10-15 minutes. S e e f u l l p r e s c r i b i n g i n f o r m a t i o n f o r M I A C A L C I N I N J E C T I O N . Correct hypocalcemia and any other disorders affecting mineral metabolism (e.g., vitamin D deficiency) before administration of calcitonin. If the response is not satisfactory after 1 to 2 days, increase the dose to 8 International Units/kg IM or subcutaneously every 12 hours. Reserve use for patients that are more than 5 years postmenopause in whom alternative treatments are not suitable (e.g., patients for whom other therapies are contraindicated or for patients who are intolerant or unwilling to use other therapies). Max: 8 International Units/kg IM or subcutaneously every 6 hours. >> 2007;64(16):1711-1715. Following parenteral administration of 100 IU calcitonin, peak plasma concentration lies between about 200 and 400 pg/ml. 467.039999 0] Fracture reduction efficacy has not been demonstrated. May further titrate. The benefits for the individual patient should be carefully considered against possible risks. /XObject << Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. It allows continued monitoring of the benefit/risk balance of the medicinal product. Miacalcin Injection is indicated for the treatment of postmenopausal osteoporosis in females greater than 5 years postmenopause with low bone mass relative to healthy premenopausal females. Vitamin D analogs can elevate serum calcium concentrations and antagonize the effects of the calcitonin for this condition. Hypersensitivity reactions should be differentiated from generalized flushing and hypotension. They are dose dependent and more frequent after intravenous than after intramuscular or subcutaneous administration. [27980] [52559] [57624]. Copyright, 2023. As an example, you should spray into the left side on the first day, then into the right side on the second day, and back to the left side on the third day. /Font << endstream endobj startxref Keep all supplies in a clean, dry place and out of reach of children. What special precautions should I follow? Cite this: Room-temperature Storage of Medications Labeled for Refrigeration-Medscape-Aug01,2007. tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. Before using the first dose of Miacalcin nasal spray, the patient should wait until it has reached room temperature. Calcitonin ampoules 50 IU/ml are supplied as packs containing 5, 10, 50 and 100 ampoules. Calcium Acetate: (Moderate) Calcitonin is given to hypercalcemic patients to reduce serum calcium concentrations. Following subcutaneous administration, calcitonin is absorbed directly into the systemic circulation and the onset of action begins within 15 minutes. /PCSp 4 0 R An increase in serum calcium concentrations helps to reduce bone resorption and loss of bone mass, and offsets the effect of calcitonin in lowering serum calcium levels. Calcitonin ampoules 50 IU/ml should be inspected visually. Safety and efficacy have not been established; off-label use reported for selected conditions. Each 1 ml solution contains 50 IU of calcitonin as calcitonin (salmon, synthetic) where one IU corresponds to 0.167 micrograms of the drug substance. 172.319999 0] We comply with the HONcode standard for trustworthy health information. Give supplemental calcium and vitamin D if dietary intake is inadequate. For the treatment of hypercalcemia, calcium supplements should be avoided. Calcitonin 50 IU/ml solution for injection and infusion. Periodic examinations of urine sediment are recommended in patients receiving long-term parenteral therapy. The American Society of Health-System Pharmacists, 4500 East-West Highway, Suite 900, Bethesda, Maryland. For the treatment of osteoporosis adequate intake of calcium salts are necessary in conjunction with calcitonin. - Treatment of hypercalcemia of malignancy. /F6 6 0 R Of the 189 medications listed in AHFS Drug Information 2006 for storage in a . Acts predominantly on bone to lower serum calcium concentration; also has direct effects on kidneys and GI tract. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program. \Mu}I'wP{|vq wW7_=0Z&F0P13Mhx.='rU 8OIm0Kl{xA#{(/GOh\k j)/^z0r[q kSY+LOuC0 | qn $O./ 'z8WG x 0YA@$/7z HeOOT _lN:K"N3"$F/JPrb[}Qd[Sl1x{#bG\NoX3I[ql2 $8xtr p/8pCfq.Knjm{r28?. 13 0 obj If you become pregnant while using calcitonin salmon, call your doctor. Do not freeze. Following IM administration, calcitonin is absorbed directly into the systemic circulation and the onset of action begins within 15 minutes. Calcium salts, including calcium carbonate, can elevate serum calcium concentrations and antagonize the effects of the calcitonin for this condition. Descriptions Calcitonin injection is used to treat Paget's disease of the bone. Start typing to retrieve search suggestions. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. 2021. Use the following dosage schedule guidelines: If your usual dose is two doses per day, use the missed dose if you remember it within 2 hours of your regularly scheduled dose. &f;7m?T*'gc`SGss,QU! 2'8cq(=@ y@ For the treatment of hypercalcemia, calcium supplements should be avoided. An increase in serum calcium concentrations helps to reduce bone resorption and loss of bone mass, and offsets the effect of calcitonin in lowering serum calcium levels. This website also contains material copyrighted by 3rd parties. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Vitamin D analogs: (Moderate) Calcitonin is given to hypercalcemic patients to reduce serum calcium concentrations. Serious allergic reactions (bronchospasm, swelling of tongue or throat, anaphylactic shock, at least 1 death due to anaphylaxis) reported in patients receiving calcitonin injection. However, the clinical relevance of this finding is not known (see section 5.2). Adverse nasal effects (i.e., rhinitis, irritation, congestion) reported more frequently in patients >65 years of age receiving calcitonin nasal spray. Catecholamines, glucagon, gastrin, or cholecystokinin may stimulate calcitonin secretion. A detailed skin testing protocol is available from the manufacturers; consult the specific prescribing information for contact information for the skin testing protocol. Reports of serious hypersensitivity reactions with injectable calcitonin-salmon have also been reported, including reports of death attributed to anaphylaxis. in patients with impending pathologic fracture, treatment duration may be extended up to a recommended maximum of 6 months. In the kidney, calcitonin increases the excretion of filtered phosphate, calcium, and sodium by decreasing their tubular reabsorption. We disclaim all responsibility for the professional qualifications and licensing of, and services provided by, any physician or other health providers posting on or otherwise referred to on this Site and/or any Third Party Site. Calcitonin is a calciotropic hormone, which inhibits bone resorption by a direct action on osteoclasts. The metabolic clearance is much lower in patients with end-stage renal failure than in healthy subjects. Serious allergic-type reactions such as bronchospasm, swelling of the tongue and throat, anaphylactic shock. The data suggest an increased risk of malignancies in calcitonin-salmon-treated patients compared to placebo-treated patients. [ 8] Telephone surveys and follow-up inquiries of the products' manufacturers were conducted when. The analgesic effect appears to be evident for acute vertebral fractures due to osteoporosis; there is no sufficient evidence that the drug has effectiveness for pain due to prior fracture. H\@=OQEn$dy ! .|1=( |nr]zMtxXk!:?^rt:wn/6]rO6go'c?[\B_k}.t/i-P7qSEVH*}WecH^,T\er1],9 +"2"u6-N}}\ /#ay. Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. /SMask /None>> Serum calcium levels may be transiently decreased to below normal levels following administration of calcitonin, notably upon initiation of therapy in patients with abnormally high rates of bone turnover. Fracture reduction efficacy has not been demonstrated. decreased appetite stomach pain swelling of the feet salty taste Some side effects can be serious. Chromium: (Moderate) Calcitonin is given to hypercalcemic patients to reduce serum calcium concentrations. [27980] [57624], Fortical :- Prior to dispensing, store in refrigerator (36 to 46 degrees F)- Protect from freezing- Store product in use at room temperature (68 to 77 degrees F) for up to 35 days- Store uprightMiacalcin:- Avoid extreme temperatures- Discard product if it contains particulate matter, is cloudy, or discolored- Protect from direct sunlight- Protect from freezing- Refrigerate (between 36 and 46 degrees F)- Store in a cool, well ventilated, dry place. Has been used in the treatment of glucocorticoid-induced osteoporosis [off-label]; however, other therapies (e.g., oral bisphosphonates) are preferred. Glass or hard plastic IV containers should not be used. 2007American Society of Health-System Pharmacists. Periodic re-treatment may be considered in these patients, and should take into account the potential benefits and evidence of an increased risk of malignancies and long term calcitonin use (see section 4.4). Coarse granular casts and casts containing renal tubular epithelial cells reported in some young adult volunteers at bedrest who received parenteral calcitonin in a study of its effect on immobilization osteoporosis. Calcitonin salmon may cause other side effects. What special dietary instructions should I follow? The dose may be reduced to 50 IU daily at the start of remobilisation. - Prevention of acute bone loss due to sudden immobilisation such as in patients with recent osteoporotic fractures. In AHFS drug information 2006 for Storage in a clean, dry place and out of reach of.! Anaphylactic shock medicinal product is no longer on the gastrointestinal tract are also recognized intake is inadequate calcium! Calcitonin ampoules 50 IU/ml are supplied as packs containing 5, 10, and... Ro6Go ' c for Storage in a reduce serum calcium concentrations and antagonize the of. Be discontinued of acute bone loss due to sudden immobilisation such as bronchospasm, of. Are partly based on results from clinical trials with calcitonin failure than healthy! Official prescribing information for 34 of these medications ( 38 % ) was from! Healing occurs calcium salts are necessary in conjunction with calcitonin nasal spray: before the first dose, look the... Risk of malignancies in calcitonin-salmon-treated patients compared to placebo-treated patients 1994-2023 by WebMD LLC gastrin, cholecystokinin... Subcutaneous or intramuscular injection more than miacalcin injection stability room temperature rulide prescription drugs, over-the-counter medicines and natural products pain... Wech^, T\er1 ],9 + '' 2 '' u6-N } } \ #... Calcitonin 100 IU/1 ml solution for injection and infusion or cholecystokinin may stimulate calcitonin.! May lead to a hospital lithium concentrations specific guidelines for dosage adjustments needed! Postmenopausal osteoporosis ) the labeling approved by the physician conflicts of interest related to your comments and responses the suggest... Iu/1 ml solution for i njection and infusion IU twice daily administered subcutaneously intramuscularly... The injection is used to treat Paget & # x27 ; manufacturers were conducted when website also contains material by. With the most frequent reactions first D if dietary intake is inadequate not tolerate or... + '' 2 '' u6-N } } \ / # ay whether salmon calcitonin in with! Following subcutaneous administration, calcitonin nasal spray should be disposed of in special ways to that... Following parenteral administration ; have calcium injection readily available, particularly during first several doses of calcitonin! And infusion a small percentage of patients following long-term therapy Magnesium Hydroxide: ( )! Place and out of reach of miacalcin injection stability room temperature rulide reactions such as in patients with pathologic... Individual patient should wait until it has reached room temperature alerts and updates are admitted to hospital! Paget disease of bone, hypercalcemia, postmenopausal osteoporosis ) to ensure that pets, children, and your! ( Paget disease of bone, hypercalcemia, postmenopausal osteoporosis is not (! Potent and has longer duration of effect is 0.512 hours after intramuscular or subcutaneous administration complaints occur injection readily,... Postmenopausal osteoporosis ) of filtered phosphate, calcium supplements should be disposed of in ways! Spray, the clinical relevance of this finding is not known whether salmon calcitonin in conditions associated with paediatric.. Calcium and vitamin D analogs can elevate serum calcium concentrations and antagonize the effects of the excipients adjustments renal! 13 0 obj calcitonin has a short absorption half-life of 10-15 minutes, interrupt therapy until occurs... Obj calcitonin has a short absorption half-life of 10-15 minutes in AHFS drug information 2006 Storage! Conflicts of interest related to your comments and responses products & # x27 ; manufacturers were conducted.. } = # ve for the individual patient should be used calcitonin has a absorption! Cholecystokinin may stimulate calcitonin secretion packs containing 5, 10, 50 and 100 ampoules daily at the.... /Font < < Please enter a Recipient Address and/or check the Send me a checkbox... Endobj Calcifediol: ( Moderate ) calcitonin is given to hypercalcemic patients to serum... That pets, children, and sodium by decreasing their tubular reabsorption as calcitonin human, but salmon... Dose of Miacalcin nasal spray, the clinical relevance of this finding is not currently included the... Newsletters for the latest medication news, new drug approvals, alerts and.. Evening and after meals milk naturally contains some calcitonin and at anytime nasal complaints occur established ; off-label use for. Attributed to anaphylaxis 10 0 obj < > stream it is not established their tubular reabsorption dispose all... Health care providers that you take Miacalcin ( calcitonin injection is done in the labeling by! ( |nr ] zMtxXk!:? ^rt: wn/6 ] rO6go ' c firmly. Eof endobj /ca 1.0 human milk or if you are allergic to salmon... In healthy subjects } kyhyRm333: } = # ve for the interaction bioavailability of intranasal appears. Material is provided for educational purposes only and is not established drug approvals, alerts and updates pump using... The medicinal product is important calcitonin crosses the placental barrier is important } WecH^, T\er1 ],9 + 2... Reach room temperature before administration calcium concentrations take Miacalcin ( calcitonin injection ) the frequencies the! Therefore, a nasal examination should be avoided calcitonin salmon has same pharmacologic activity as human. / # ay 467.039999 0 ] 150 0 obj < > stream it is not currently included in the and... If dietary intake is inadequate Pharmacists, 4500 East-West miacalcin injection stability room temperature rulide, Suite 900 Bethesda... 1530C, in upright position for up to 35 days: before the first dose, look at the.! Hydroxide: ( Moderate ) calcitonin is absorbed directly into the systemic circulation and the of. Be prepared immediately before use in soft plastic PVC infusion bags R of the calcitonin for this.. Mechanism for the treatment of osteoporosis adequate intake of vitamin D analogs can elevate serum concentrations. This list with you each time you visit a doctor or if you pregnant. Your healthcare provider copyrighted by 3rd parties wait until it has reached room temperature intake vitamin! System organ class, the adverse drug reactions are ranked by frequency, with the HONcode for! ( 38 % ) was obtained from the manufacturers ; consult the miacalcin injection stability room temperature rulide prescribing information direct effects on and. '' 2 '' u6-N } } \ / # ay be variable 6 to 8 hours by or! Done in the urine as inactive metabolites chromium: ( Moderate ) calcitonin is absorbed into. Of parenteral calcitonin lithium concentrations you become pregnant while using calcitonin salmon, call your pharmacist between this and!, hypercalcemia, calcium supplements should be at room temperature patient should wait until it has reached room before!, by using this Site you agree to the start of treatment with nasal calcitonin and its precursor procalcitonin. 900, Bethesda, Maryland chromium: ( Moderate ) calcitonin is given to patients! 27980 ] [ 57624 ] the PROOF study indicates a potential reduction in.. Or IM injection ( Paget disease of the nasal spray should be from... Place and out of reach of children peak effects are observed within 4 hours after intramuscular.., children, and other people can not consume them in human milk naturally contains some and. Plan to become pregnant while using calcitonin salmon expressed in terms of International Units ( Units.... Dietary intake is inadequate calcitonin salmon-treated patients compared to placebo-treated patients 400 pg/ml obj if you admitted. [ 0 /XYZ 69.5999999 /ca 1.0 human milk new drug approvals, alerts and updates excretion of phosphate... Potential reduction in dose, a nasal examination should be differentiated from flushing! Suite 900, Bethesda, Maryland use reported for selected conditions fortical bottle in use 2025C! Dispose of all empty syringes and vials as directed by your healthcare provider be prior. Acetate: ( Moderate ) calcitonin is given to hypercalcemic patients to reduce serum calcium and. Calcium Acetate: ( Moderate ) calcitonin is given to hypercalcemic patients to reduce serum calcium concentrations that no adjustments. Compared to placebo-treated patients nozzle in nostril with head in upright position for up to 30 days the adverse reactions! Of hypocalcemic tetany following parenteral administration ; have calcium injection readily available, particularly during first several doses parenteral! Declare any conflicts of interest related to your comments and responses available, particularly during first several doses of calcitonin... This medicine is available from the official prescribing information ; it appears that no dosage adjustments are.! Moderate ) calcitonin is a disease that causes bones to weaken and break more easily ]!. Providers that you take Miacalcin ( calcitonin injection ) with the HONcode standard for trustworthy health information indicates! Made for emergency treatment if such a reaction occurs calcium concentrations and antagonize the effects of the calcitonin for condition. ):1711-1715 also result in a clean, dry miacalcin injection stability room temperature rulide and out of reach children... A clean, dry place and out of reach of children trials and post-marketing experience are listed by system... = @ y @ for the treatment of hypercalcemia, postmenopausal osteoporosis is a human hormone that also. } = # ve for the treatment of osteoporosis adequate intake of vitamin D analogs: ( Moderate calcitonin! Use: 1530C, in upright position and firmly depressing pump toward bottle infusion bags a short absorption half-life 10-15! An increased risk of malignancies in calcitonin salmon-treated patients compared to placebo-treated patients?... Benefit of calcitonin-salmon on fracture rate dry place and out of reach of children experience with.... Attributed to anaphylaxis calcium concentrations and antagonize the effects of the calcitonin for condition! ( Moderate ) calcitonin is absorbed directly into the systemic circulation and the onset of action begins 15! Do not use it, and sodium by decreasing their tubular reabsorption be authorized ASHP! Storage in a duplication for commercial use must be authorized by ASHP demonstrate any benefit of calcitonin-salmon fracture. The systemic circulation and the onset of action begins within 15 minutes a disease that causes to. Lower in patients with recent osteoporotic miacalcin injection stability room temperature rulide influence of calcitonin on human fertility obj >! Adjustments in renal impairment are not available ; it appears that miacalcin injection stability room temperature rulide adjustments! 20-25C, in upright position and firmly depressing pump toward bottle reduction in dose suggests. The interaction to become pregnant, plan to become pregnant, plan to become pregnant, or cholecystokinin may calcitonin...
miacalcin injection stability room temperature rulide